June 29, 2017

Problem & Need – Diabetic Foot Ulcers

Diabetic Foot Ulcer Treatments

It is estimated by 2015 there will be some 592 million diabetics worldwide and 25% will suffer at some time with non-healing diabetic foot ulcers. There current paradigm is keep the ulcer clean and prevent infection and amputation.

The Need

There is an urgent need to develop a wound healing delivery that can increase the efficacy while minimizing any side effects. Current treatments include; negative pressure wound devices, advanced wound dressing products, biosynthetics, hyperbaric oxygen treatment, tissue engineering, skin substitutes, growth factors and biologic substances. Some of these treatments are very expensive and lack efficacy. Over the counter treatments are not proven or approved strategies to treat or accelerate wound healing.

The current approved treatments are skin grafts and a cream that contains a recombinant growth factor. However, this cream has been given a Black Box, may increase incidences of malignant tumors, is of limited use, and is very expensive.It is estimated by 2015 there will be some 592 million diabetics worldwide and 25% will suffer at some time with non-healing diabetic foot ulcers. There current paradigm is keep the ulcer clean and prevent infection and amputation.

MangoGen's Solution - A Gene-Delivering Film Dressing

MangoGen’s solution is to develop a gene-delivering film dressing that will promote and accelerate wound healing by delivering a gene for a growth factor that will be transiently expressed by the local cells in and around the ulcer.

2019