September 26, 2014

Working Solutions

Global Working Solutions

tool iconCurrently, there are over 50 companies working on numerous approaches to improve efficacy and reduce ISR.
These include:
Improved stent architectures
New metal alloys and polymer coats
More efficient Drug-Eluting Stents (DES)
Bioresorbable stents

MangoGen’s Solution

MangoGen has invented a new bio-therapeutic delivery mechanism that utilizes a genetically engineered insect virus (baculovirus) encapsulated in a protective nanoparticle. Attached to a suitable matrix, the nanoparticle-encapsulated virus can deliver a specific gene to a very exact location within the body.
Our first application is to address wound healing and  re-endothelization of a stented blood vessel.

The baculovirus is a very safe and relatively cheap vehicle that can deliver designed genetic therapy and treatments to a local site (e.g. endothelium).

Learn more about:
baculoviruses here
nanoparticles here
MangoGen’s Proof-of-Concept here