MangoGen has data to clearly demonstrate that baculoviruses can deliver human genes to cells in culture, and when coated onto a device placed in vivo. For example, placing a baculoviral coated stent in a canine damaged femoral artery model the results clearly demonstrates the following:
- Baculoviruses can be encapsulated and coated onto a cardiac stent
- After deployment in situ, the baculoviruses are released and enter local cells around the stent
- The human gene, Vegf, was transcribed and the expressed growth factor was released
- The rate of wound healing around the stent was accelerated
- A reduced incidence of in-stent re-stenosis was observed
- An improved blood flow and reduced neointimal was observed in vessels that had Vegf gene
These findings demonstrate the potential of this newly developed baculovirus-based biotherapeutic stent to ameliorate damaged vascular biology and diminish re-narrowing (ISR) of a blood vessel stent by inhibiting neointima formation.