January 15, 2015

Key Data

Key Data

MangoGen have performed a large animal model (canine femoral artery) and the results clearly demonstrates the following:

  1. Baculoviruses can be encapsulated and coated onto a cardiac stent
  2. After deployment in situ, the baculoviruses are rleased and enter local cells around the stent
  3. The human gene, Vegf, was transcribed and the expressed growth factor was released
  4. The rate of wound healing around the stent was accelerated
  5. A reduced incidence of in-stent re-stenosis was observed
  6. An improved blood flow and reduced neointimal was observed in vessels that had Vegf gene
These findings demonstrate the potential of this newly developed baculovirus-based biotherapeutic stent to ameliorate damaged vascular biology and diminish re-narrowing (ISR) of a blood vessel stent by inhibiting neointima formation.
Data published in Nature Scientific Reports (Paul et al 2013).
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