MangoGen have performed a large animal model (canine femoral artery) and the results clearly demonstrates the following:
- Baculoviruses can be encapsulated and coated onto a cardiac stent
- After deployment in situ, the baculoviruses are rleased and enter local cells around the stent
- The human gene, Vegf, was transcribed and the expressed growth factor was released
- The rate of wound healing around the stent was accelerated
- A reduced incidence of in-stent re-stenosis was observed
- An improved blood flow and reduced neointimal was observed in vessels that had Vegf gene
These findings demonstrate the potential of this newly developed baculovirus-based biotherapeutic stent to ameliorate damaged vascular biology and diminish re-narrowing (ISR) of a blood vessel stent by inhibiting neointima formation.
Data published in Nature Scientific Reports (Paul et al 2013).