To protect the baculovirus from serum inactivation and to achieve a controlled release at the target site, the baculovirus nanohybrids are encapsulated.
Thus, this new generation of gene-delivering stent (GeDSs) can efficiently deliver angiogenic vascular genes, such as vascular Endothelial Growth factor (Vegf) to the damaged vasculature and promote wound healing.
MangoGen has also coated encapsulated baculoviruses on a number of matrices, including:
- Cr/Co Stents
- Stainless steel
- Medical grade plastics
MangoGen’s platform technology enables the development of many other gene-delivering medical devices beyond the focused products (stents, film-dressings, sutures and creams).
Key Milestone Reached
MangoGen can coat multiple medical devices such as Cr/Co stents, film-dressings and sutures, dry and store at room temperature for >20 weeks and maintain the bio-viability of the baculovirus.