January 14, 2015


To protect the baculovirus from serum inactivation and to achieve a controlled release at the target site, the baculovirus nanohybrids were encapsulated within poly(lactic-co-glycolic acid) (PLGA) nanospheres.
Thus, this new generation of gene-eluting stent (GESs) device
can efficiently deliver angiogenic vascular genes, such as Vascular Endothelial Growth Factor, VEGF) to the affected site and induce favorable therapeutic effect in the local vasculature to promote wound healing.